转棒实验是运动协调方面药物筛选的重要方法。根据 N.W Dunham 和 T.S Miya 1957年的论文。Ugo Basile在1960年设计了第一台RotaRod转棒仪。

关于方法

§N.W. Dunham & T.S. Miya: “A Note on a Sinple Apparatus for Detecting Neurological Deficit in Rats & Mice“J. Am. Pharmaceut. Assoc., Scientific Edit., XLVI: No. 3,1957

§B.J. Jones & D.J. Roberts: “The Quantitative Measurement of Motor Inco-ordination in Naive Mice Using an Accelerating Rotarod“J. Pharm. Pharmac.: 20: 302-304,1968

使用转棒技术的相关文献

L. Micheli et alia: “Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats” Eur. J. Pharmacol. 754 : 73-81, 2015

L. A. Griffiths et alia: “Knocking Down Metabotropic Glutamate Receptor 1 Improves Survival And Disease Progression in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis” J. of Pain, accepted manuscript, 2015

JV. Jokinen et alia: “Pregabalin enhances the antinociceptive effect of oxycodone and morphine in thermal models of nociception in the rat without any pharmacokinetic interactions” Eur. J. Pain DOI: 10.1002/ejp.728, 2015

JF. Barthel et alia: “Long-term Application of Glycine Transporter Inhibitors Acts Antineuropathic and Modulates Spinal Nmethyl-D-aspartate Receptor Subunit NR-1 Expression in Rats” Anesthesiology 121.1: 160-169, 2014

C.D. Heldermon et alia: “Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB” Molecular Therapy 15(5): 873-880, 2010 (rocking,mouse)