足底测试仪是用以测量啮齿类动物对红外热刺激的反应。聚焦红外光源于动物足底，按下开关，等待动物缩回受测爪，仪器自动记录红外光强度和持续时间。实验数据会显示在液晶屏上，也可导入闪存中，或在通过USB数据线导入至电脑中。

命令：	软键		数据转移：	配备的闪存
数据读取：	液晶屏显示		电源：	universal mains 85-264 VAC, 50-60Hz
打印：	热敏打印机（需另外购买）		工作温度	15°- 30°C
开始：	红外光源开关		声级：	< 70 dB
红外光强度：	01-99级间可调		校准：	红外辐射计
反应时间：	显示在液晶屏上；分辨率为0.1s		连接电脑：	DELTA 9-pin连接器.参看说明书3.5
红外灯泡： 规格： 动物罩子： 净重： 毛重： 包装规格：	Halogen "Bellaphot", Mod. 64607 OSRAM, 8V-50W 85 x 40 x 35 cm 3个，每个20x20x14(h)cm 13.0kg 约27.5kg 109 x 53 x 55 cm

足底测试仪刺激强度值（红外热辐射值）对照表（单位：mW/cm2）

方法

- D.C. Yeomans & H.K. Proudfit: “Characterization of the Foot Withdrawal Response to Noxious Radiant Heat in the Rat” Pain 59: 85-97, 1994.

- K.M. Hargreaves, R. Dubner, F. Brown, C. Flores and J. Joris: "A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hyperalgesia." Pain 32: 77-88, 1988.

提及UB产品的文献

- V. Vacca et alia: “Botulinum Toxin A Increases Analgesic Effects of Morphine, Counters Development of Morphine Tolerance and Modulates Glia Activation and μ Opioid Receptor Expression in Neuropathic Mice” Brain, Behav and Immunity 32: 40-50, 2013

- A. Finley et alia: “Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism” PLoS ONE 8(1): e55255, 2013

- J. Donnerer et alia: “The Pain Pathway in the Rat following Noxious Thermal Stimulation: Effect of Morphine on pERK1/2 and TRPV1 at the Dorsal Horn Level, and on Hyperalgesia” Pharmacology 92: 32-38, 2013

- M. Arai et alia: “The miRNA and mRNA Changes in Rat Hippocampi after Chronic Constriction Injury”Pain Medicine 14 (5): 720-729, 2013

- P.J. Austin et alia: “G. Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats” JoVE 61, e3393, doi:10.3791/3393, 2012 http://www.jove.com/video/3393/chronic-constriction-sciatic-nerve-pain-hypersensitivity-testing

- H.N. Kim et alia: “Electroacupuncture Inhibits Phosphorylation of Spinal Phosphatidylinositol 3-kinase/Akt in a Carrageenan-induced Inflammatory Rat Model” Brain Res. Bulletin 87 (2-3): 199-204,2012

- D. Piomelli et alia: ”Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism” Nature NSC, 2010

- C.B. Vaegter et alia: ”Sortilin Associates with Trk Receptors to Enhance Anterograde Transport and Neurotrophin Signaling” Nature NSC, 2010

- O. Ortiz et alia: “Associative Learning and CA3–CA1 Synaptic Plasticity Are Impaired in D1R Null,Drd1a-/- Mice and in Hippocampal siRNA Silenced Drd1a Mice” J. Neuroscience 30 (37): 12288-12300,2010

- M. Rosemann et alia: “Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3416insGMice” Mamm Genome 21: 12-27, 2010

- Mark J. Field et alia: “Detection of Static and Dynamic Components of Mechanical Allodynia in Rat Models of Neuropathic Pain: Are They Signalled by Distinct Primary Sensory Neurones?” Pain 83: 303-311, 1999

- Fred Lembeck: “Epibatine: High Potency and Broad Spectrum Activity on Neuronal and Neuromuscular Nicotinic Acetylcholine Receptors” Naunyn-Schmiedeberg’s Arch. Pharmacol. 359:378-385, 1999

- Hartmut Buerkle et alia: “Experimental Arthritis in the Rat Does Not Alter the Analgesic Potency of Intrathecal or Intraarticular Morphine” Anesth. Analg. 89: 403-408, 1999.

- F.G. Garrett, P.L. Durham et alia: “Validation of a Novel Rat-Holding Device for studying heat- and mechanical-Evoked Trigemi­nal Nocifensive Behavioral Responses” J. Orofacial Pain, 26 (4): 336- 344, 2012

- F.G. Garrett, P.L. Durham et alia: “Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus” Poster presented at SFN 201