压痛仪根据Randall-Selitto理论设计，是进行压爪实验的经典仪器。实验时，将啮齿类动物的爪置于圆柱形底座，操作员踩压脚踏板，其上方的圆锥形推进器往爪上施力。

关于方法

·         L.O. Randall and J.J. Selitto:“A Method for Measurement of Analgesic Activity on Inflamed Tissue”Arch. Int. Pharmacodyn. CXI, No. 4: 409-419,1957.

涉及压痛仪（大鼠）

·         K. Walker et alia: “The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain“J. Pharmacol. Exper. Therap.304, No. 1: 56-62,2003.

·         S. Asfaha et alia: “Proteinase-Activated Receptor-1 Agonists attenuate nociception in Response to Noxious Stimuli“Br. J. Pharmacol.135: 1101-1106,2002.

·         K.O. Aley et alia: “Chronic Hypersensitivity for Inflammatory Nociceptor sensitization Mediated by the єIsozyme of Protein Kinase C“J. Neuroscience20 (12): 4680-4685,2000.

·         O.A. Kochuvelikakam and J.D. Levine: “Role of Protein Kinase A in the Maintenance of Inflammatory Pain“J. Neuroscience.19(6): 2181-2186,1999.

涉及压痛仪（小鼠）

·         H. Saegusa et alia: “Suppression of Inflammatory and Neuropathic Pain Symptoms in Mice Lacking the N-type Ca²⁺Channel“The EMBO Journal.20, No. 10: 2349-2356,2001.

·         W. Binder et alia: “Effect of Gender on Anti-Inflammatory and Analgesic Actions of Two К-Opioids“J. Pharmacol. Exper. Therap.292: 303-309,2000.